He uses a cartoon clip to explain the anatomy of the nasal cavity and where mucus is produced. He then sets up a giant tube with nose hairs to show how the nose works. The hairs are meant to filter air before it goes into the body. Then he explains that snot and mucus trap bacteria and larger particles from going into the lungs. They blow feathers into one end of the "nose" and show that clean air is coming out the other end because the mucus trapped the feathers.
Billy's nose is whisked away by a Nasalmancer. The nasalmancer admires Billy's nose for its size, then mishandles it to comment about how spacious it is. When Billy tells him to stop and tries to invoke empathy by telling the nasalmancer he wouldn't do the same to his own nose, the nasalmancer cries because he doesn't have a nose.
Per Thomas Edison's suggestion, The Secret Labbers visit Frederick Soddy to better understand radioactive decay.
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Beakmans explains that onions make you cry because of the chemical that gets into your nose. He then uses a schematic of a bathroom drainage system as a metaphor for how your nose, mouth and eyes are all connected. Lester sneezes when his nose was tickled and this causes his eyes to shut because the muscles are connected.