Dave Shutton, an investigative reporter, approaches Bart and Lisa as they're fishing and talks to them. In the middle of their conversation, Bart catches a genetically-mutated fish with three eyes, earning him a spot on the front page of the newspaper.
Sophie discusses how plants and animals need to compete in order to survive and the role that adaptations play in their ability to survive. She explains how several animals and bugs have adapted to become better suited to surviving in city environments.
Jean Grey addresses the United States Senate on the topic of mutants. Senator Kelly is opposed to them and convinces the audience that they are dangerous. He advocates for having mutants register themselves so that the government knows who they are and what they are capable of doing.
Hank describes the five factors that explain changes in allele frequency, which are at the heart of how and why evolution happens. The five factors he describes are: natural selection, sexual selection, mutation, genetic drift, and gene flow.