Homer brings together relatives from the tri-state area in an attempt to prove to Lisa that there are no problems with the genes in the Simpson family. When he fails to prove the success of his relatives, Marge suggests he ask the women instead of the men. The women are successful, and they state that the defective Simpson gene affects only the men because it is on the Y chromosome. Important to note is that some common, real-life defects and deficiencies occur more frequently in men because they have only one X chromosome, not because the defective gene is on their Y chromosome.
On a family trip to Cuba, Grampa Simpson becomes depressed and unwilling to partake in activities. He cheers up when he spots an old American car from his times and goes for a ride in it with a native Cuban. Both during and after the ride, Grampa feels reinvigorated and connected with his youth. The Cuban resident references a study conducted by Ellen Langer in which seniors felt young again once exposed to objects from their youth.