The Powerpuff Girls want to fit in school better and they beg the professor to make them a potion to make them older. The girls drink too much and become senior citizens. At the breakfast table, Buttercup's teeth fall out, Bubbles begins to lose her hearing, and Blossom becomes forgetful.
Penelope is under a lot of stress when she meets Schneider. They have a conversation, and Schneider notices that she doesn't sound like herself. Penelope takes out her aggrevation on him.
Charlie takes an "intelligence pill" and claims it has helped him invent a way for spiders to speak to cats. The researchers quickly diffuse this claim and credit the placebo effect for increasing Charlie's self-confidence, arrogance, and perceived intelligence with no actual effects on his intelligence.